"You Do Something to Me" is a song written by Cole Porter. It is notable in that it was the first number in Porter's first fully integrated-book musical Fifty Million Frenchmen (1929). In the original production, the song was performed by Genevieve Tobin and William Gaxton, performing the roles of Looloo Carroll and Peter Forbes, respectively.
There are two verses and two rounds of the chorus. The song has been described as "a tender prequel" to "Let's Do It, Let's Fall In Love," Porter's first popular song
The song has been revived and recorded by artists including:
- Perry Como on "So Smooth" (RCA Victor album, 1955)
- Howard McGillin and Susan Powell in 1991.
- Mario Lanza
- Frank Sinatra
- Marlene Dietrich
- Doris Day
- Sonny Rollins
- Susannah McCorkle
- Bryan Ferry on As Time Goes By (1999)
- Sinéad O'Connor on Red Hot + Blue (1990)
- Ella Fitzgerald, the First Lady of Song, recorded this song on both her Cole Porter Songbook albums and on her Pablo classic, Ella à Nice
- Bing Crosby recorded the song in 1955 for use on his radio show and it was subsequently included in the box set The Bing Crosby CBS Radio Recordings (1954-56) issued by Mosaic Records (catalog MD7-245) in 2009.
- Bette Midler's version of the song plays over the final credits of the 1991 film Scenes from a Mall, which starred her and Woody Allen.
- According to the liner notes for It's De Lovely — The Authentic Cole Porter Collection, the line "the voodoo that you do so well" is quoted in the 1993 Salt-N-Pepa song "Shoop".
- The "voodoo" line is also quoted by Hedley Lamarr (Harvey Korman) in the 1974 film Blazing Saddles as he exhorts his gang to attack a frontier town. The headline "Do Do that Voodoo" was used for a Paul Krugman editorial in the New York Times in 2011. The column was about Trickle Down economics. 
- "discogs.com". discogs.com. Retrieved March 5, 2021.
- "A Bing Crosby Discography". BING magazine. International Club Crosby. Retrieved December 10, 2017.
- "allmusic.com". allmusic.com. Retrieved December 10, 2017.
- Friedwald, Will (2004). Bluebird Presents: It's De Lovely - The Authentic Cole Porter Collection (liner notes). New York: BMG Music. p. 6."We don't even need the additional evidence of rock and country artists doing albums of standards that include Porter songs, or the recent rap hit "Shoop" which quotes the phrase "the voodoo that you do so well" from Porter's 1929 'You Do Something To Me.'"
- Do Do That Voodoo, Paul Krugman, New York Times, MAY 17, 2011